AZD 9668
Alvelestat
CAS: 848141-11-7
Molecular Formula: C25H22F3N5O4S
AZD 9668 - Names and Identifiers
AZD 9668 - Physico-chemical Properties
| Molecular Formula | C25H22F3N5O4S |
| Molar Mass | 545.53 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 207-209°C |
| Boling Point | 780.4±60.0 °C(Predicted) |
| Solubility | 25°C: DMSO |
| Appearance | Solid |
| Color | White |
| pKa | 11.00±0.20(Predicted) |
| Storage Condition | -20°C Freezer |
| Use | Alvelestat (AZD9668) is an orally available, highly selective neutrophil elastase (NE) inhibitor with IC50 and Ki of 12 nM and 9.4 nM respectively, and its selectivity is at least 600 times higher than other serine proteases. |
| In vitro study | AZD9668 inhibits plasma NE activity in whole blood stimulated by zymosan, and AZD9668 also inhibits NE activity in supernatants in which stimulated cells have been exposed to antigen and on the surface of stimulated Polymorphonuclear cells. |
| In vivo study | In mice and rats, AZD9668 (oral) prevented lung injury of human NE induction. AZD9668 significantly reduced the number of BAL neutrophils and BAL IL-1β in a mouse model of smoke-induced airway inflammation. In a guinea pig model of long-term exposure to smoke, AZD9668 prevented spatial enlargement and small airway wall remodeling. |
AZD 9668 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.833 ml | 9.165 ml | 18.331 ml |
| 5 mM | 0.367 ml | 1.833 ml | 3.666 ml |
| 10 mM | 0.183 ml | 0.917 ml | 1.833 ml |
| 5 mM | 0.037 ml | 0.183 ml | 0.367 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: Alvelestat Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Alvelestat Request for quotationCAS: 848141-11-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Alvelestat Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AZD9668 Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Alvelestat Visit Supplier Webpage Request for quotation
CAS: 848141-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 848141-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Alvelestat Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Alvelestat Request for quotationCAS: 848141-11-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Alvelestat Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AZD9668 Visit Supplier Webpage Request for quotationCAS: 848141-11-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Alvelestat Visit Supplier Webpage Request for quotation
CAS: 848141-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 848141-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
AZD 9668
2-Hydroxypyridine N-oxide
Thioacetic acid S-potassium salt
1010809-74-1
206002-47-3
6523-63-3
2-Fluoro-6-nitrophen
Sorbitan oleate
3577-01-3
FMOC-PRO-PRO-OH
2-Hydroxypyridine N-oxide
Thioacetic acid S-potassium salt
1010809-74-1
206002-47-3
6523-63-3
2-Fluoro-6-nitrophen
Sorbitan oleate
3577-01-3
FMOC-PRO-PRO-OH